Benefits and harms of lower blood pressure treatment targets: systematic review and meta-analysis of randomised placebo-controlled trials.

ABSTRACT:

Objectives

To assess the effect of antihypertensive treatment in the 130-140 mm Hg systolic blood pressure range.

Design

Systematic review and meta-analysis.

Information sources

PubMed, CDSR and DARE were searched for the systematic reviews, which were manually browsed for clinical trials. PubMed and Cochrane Central Register of Controlled Trials were searched for trials directly in February 2018.

Eligibility criteria

Randomised double-blind trials with ≥1000 patient-years of follow-up, comparing any antihypertensive agent against placebo.

Data extraction and risk of bias

Two reviewers extracted study-level data, and assessed risk of bias using Cochrane Collaborations risk of bias assessment tool, independently.

Main outcomes and measures

Primary

SUBMITTER: Brunstrom M 

PROVIDER: S-EPMC6773352 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature