Differences in inherited risk among relatives of hereditary prostate cancer patients using genetic risk score.

ABSTRACT:

Purpose

Family history assigns equivalent risk to all relatives based upon the degree of relationship. Recent genetic studies have identified single nucleotide polymorphisms (SNPs) that can be used to calculate a genetic risk score (GRS) to determine prostate cancer (PCa) risk. We sought to determine whether GRS can stratify PCa risk among individuals in families considered to be at higher risk due their family history of PCa.

Materials and methods

Family members with hereditary PCa were recruited and genotyped for 17 SNPs associated with PCa. A GRS was calculated for all subjects. Analyses compared the distribution of GRS values among affected and unaffected family members of varying relationship degrees.

Results

Data was available for 789 family members of probands

SUBMITTER: Helfand BT 

PROVIDER: S-EPMC6773522 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature