Plasma Biomarkers in Predicting Renal Recovery from Acute Kidney Injury in Critically Ill Patients.

ABSTRACT:

Background

Numerous studies have suggested a possible role for acute kidney injury (AKI) biomarkers in predicting renal recovery both before and after renal replacement therapy (RRT). However, definitions for recovery and whether to include patients dying but free of RRT may influence results.

Objectives

To validate plasma neutrophil gelatinase-associated lipocalin (pNGAL) as a useful biomarker for predicting or improving the ability of clinical predictors alone to predict recovery following AKI, including in our model plasma B-type natriuretic peptide (pBNP) to account for cardiovascular events.

Methods

We analyzed 69 patients enrolled in the Acute Renal Failure Trial Network study. pNGAL and pBNP were measured on days 2, 7, and 14. We analyzed their predictive abili

SUBMITTER: Fiorentino M 

PROVIDER: S-EPMC6773527 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature