Meta-analysis of epidural analgesia in patients undergoing pancreatoduodenectomy.

ABSTRACT:

Background

The optimal analgesic technique after pancreatoduodenectomy remains under debate. This study aimed to see whether epidural analgesia (EA) has superior clinical outcomes compared with non-epidural alternatives (N-EA) in patients undergoing pancreatoduodenectomy.

Methods

A systematic review with meta-analysis was performed according to PRISMA guidelines. On 28 August 2018, relevant literature databases were searched. Primary outcomes were pain scores. Secondary outcomes were treatment failure of initial analgesia, complications, duration of hospital stay and mortality.

Results

Three RCTs and eight cohort studies (25 089 patients) were included. N-EA treatments studied were: intravenous morphine, continuous wound infiltration, bilateral paravertebral thoracic

SUBMITTER: Groen JV 

PROVIDER: S-EPMC6773638 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature