Metabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction.

ABSTRACT: Stress negatively impacts gut and brain health. Individual differences in response to stress have been linked to genetic and environmental factors and more recently, a role for the gut microbiota in the regulation of stress-related changes has been demonstrated. However, the mechanisms by which these factors influence each other are poorly understood, and there are currently no established robust biomarkers of stress susceptibility. To determine the metabolic and microbial signatures underpinning physiological stress responses, we compared stress-sensitive Wistar Kyoto (WKY) rats to the normo-anxious Sprague Dawley (SD) strain. Here we report that acute stress-induced strain-specific changes in brain lipid metabolites were a prominent feature in WKY rats. The relative abundance of Lactococ

SUBMITTER: Bassett SA 

PROVIDER: S-EPMC6773725 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature