Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation.

ABSTRACT:

Purpose

Respiratory muscle weakness frequently develops in critically ill patients and is associated with adverse outcome, including difficult weaning from mechanical ventilation. Today, no drug is approved to improve respiratory muscle function in these patients. Previously, we have shown that the calcium sensitizer levosimendan improves calcium sensitivity of human diaphragm muscle fibers in vitro and contractile efficiency of the diaphragm in healthy subjects. The main purpose of this study is to investigate the effects of levosimendan on diaphragm contractile efficiency in mechanically ventilated patients.

Methods

In a double-blind randomized placebo-controlled trial, mechanically ventilated patients performed two 30-min continuous positive airway pressure (CPAP) trials

SUBMITTER: Roesthuis L 

PROVIDER: S-EPMC6773912 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature