An Integrated System Biology Approach Yields Drug Repositioning Candidates for the Treatment of Heart Failure.

ABSTRACT: Identifying effective pharmacological treatments for heart failure (HF) patients remains critically important. Given that the development of drugs de novo is expensive and time consuming, drug repositioning has become an increasingly important branch. In the present study, we propose a two-step drug repositioning pipeline and investigate the novel therapeutic effects of existing drugs approved by the US Food and Drug Administration to discover potential therapeutic drugs for HF. In the first step, we compared the gene expression pattern of HF patients with drug-induced gene expression profiles to obtain preliminary candidates. In the second step, we performed a systems biology approach based on the known protein-protein interaction information and targets of drugs to narrow down preliminar

SUBMITTER: Yang G 

PROVIDER: S-EPMC6773955 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature