A family of orthologous proteins from centipede venoms inhibit the hKir6.2 channel.

ABSTRACT: Inhibitors targeting ion channels are useful tools for studying their functions. Given the selectivity of any inhibitor for a channel is relative, more than one inhibitor of different affinities may be used to help identify the channel in a biological preparation. Here, we describe a family of small proteins in centipede venoms that inhibit the pore (hKir6.2) of a human ATP-sensitive K⁺ channel (hK_ATP). While the traditional peptide-sequencing service gradually vanishes from academic institutions, we tried to identify the sequences of inhibitory proteins purified from venoms by searching the sequences of the corresponding transcriptomes, a search guided by the key features of a known hKir6.2 inhibitor (SpTx1). The candidate sequences were cross-checked against the mas

SUBMITTER: Ramu Y 

PROVIDER: S-EPMC6773964 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature