Conserved Central Intraviral Protein Interactome of the <i>Herpesviridae</i> Family.

ABSTRACT: Protein interactions are major driving forces behind the functional phenotypes of biological processes. As such, evolutionary footprints are reflected in system-level collections of protein-protein interactions (PPIs), i.e., protein interactomes. We conducted a comparative analysis of intraviral protein interactomes for representative species of each of the three subfamilies of herpesviruses (herpes simplex virus 1, human cytomegalovirus, and Epstein-Barr virus), which are highly prevalent etiologic agents of important human diseases. The intraviral interactomes were reconstructed by combining experimentally supported and computationally predicted protein-protein interactions. Using cross-species network comparison, we then identified family-wise conserved interactions and protein complexe

SUBMITTER: Hernandez Duran A 

PROVIDER: S-EPMC6774017 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature