Light-Addressable Nanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and Dynamic Magnetic Resonance Imaging of Arthritis.

ABSTRACT: Design of novel nanoplatforms with single imaging elements for dynamic and enhanced T ₁/T ₂-weighted magnetic resonance (MR) imaging of diseases still remains significantly challenging. Here, a facile strategy to synthesize light-addressable ultrasmall Fe₃O₄ nanoparticles (NPs) that can form nanoclusters (NCs) under laser irradiation for enhanced and dynamic T ₁/T ₂-weighted MR imaging of inflammatory arthritis is reported. Citric acid-stabilized ultrasmall Fe₃O₄ NPs synthesized via a solvothermal approach are linked with both the arthritis targeting ligand folic acid (FA) and light-addressable unit diazirine (DA) via polyethylene glycol (PEG) spacer. The formed ultrasmall Fe

SUBMITTER: Li X 

PROVIDER: S-EPMC6774037 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature