Synthesis of Ultrathin Biotite Nanosheets as an Intelligent Theranostic Platform for Combination Cancer Therapy.

ABSTRACT: Biotite, also called black mica (BM), is a group of sheet silicate minerals with great potential in various fields. However, synthesis of high-quality BM nanosheets (NSs) remains a huge challenge. Here, an exfoliation approach is provided that combines calcination, n-butyllithium exchange and intercalation, and liquid exfoliating processes for the high-yield synthesis of ultrathin BM NSs. Due to the presence of MgO, Fe₂O₃, and FeO in these NSs, PEGylated BM can be engineered as an intelligent theranostic platform with the following unique features: i) Fe³⁺ can damage the tumor microenvironment (TME) through glutathione consumption and O₂ production; ii) Generated O₂ can be further catalyzed by MgO with oxygen vacancy to generate

SUBMITTER: Ji X 

PROVIDER: S-EPMC6774039 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature