Short stop is allelic to kakapo, and encodes rod-like cytoskeletal-associated proteins required for axon extension.

ABSTRACT: short stop (shot) is required for sensory and motor axons to reach their targets in the Drosophila embryo. Growth cones in shot mutants initiate at the normal times, and they appear normal with respect to overall morphology and their abilities to orient and fasciculate. However, sensory axons are unable to extend beyond a short distance from the cell body, and motor axons are unable to reach target muscles. The shot gene encodes novel actin binding proteins that are related to plakins and dystrophin and expressed in axons during development. The longer isoforms identified are predicted to contain an N-terminal actin binding domain, a long central triple helical coiled-coil domain, and a C-terminal domain that contains two EF-hand Ca(2+) binding motifs and a short stretch of homology to the

SUBMITTER: Lee S 

PROVIDER: S-EPMC6774164 | biostudies-literature | 2000 Feb

REPOSITORIES: biostudies-literature