Strategies for robust and accurate experimental approaches to quantify nanomaterial bioaccumulation across a broad range of organisms.

ABSTRACT: One of the key components for environmental risk assessment of engineered nanomaterials (ENMs) is data on bioaccumulation potential. Accurately measuring bioaccumulation can be critical for regulatory decision making regarding material hazard and risk, and for understanding the mechanism of toxicity. This perspective provides expert guidance for performing ENM bioaccumulation measurements across a broad range of test organisms and species. To accomplish this aim, we critically evaluated ENM bioaccumulation within three categories of organisms: single-celled species, multicellular species excluding plants, and multicellular plants. For aqueous exposures of suspended single-celled and small multicellular species, it is critical to perform a robust procedure to separate suspended ENMs and sma

SUBMITTER: Petersen EJ 

PROVIDER: S-EPMC6774209 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature