A longitudinal assessment of retinal function and structure in the APP/PS1 transgenic mouse model of Alzheimer's disease.

ABSTRACT:

Background

A great body of evidence suggests that there are retinal functional and structural changes that occur in Alzheimer's disease (AD). However, whether such changes are primary or secondary remains to be elucidated. We studied a range of retinal functional and structural parameters in association with AD- specific pathophysiological markers in the double transgenic APP/PS1 and control mice across age.

Methods

Electroretinogram (ERG) and optical coherence tomography (OCT) was performed in APP/PS1 and wild type (WT) control mice every 3 months from 3 to 12 months of age. For functional assessment, the a- and b-wave of the ERG, amplitude of oscillatory potentials (OP) and the positive scotopic threshold response (pSTR) were quantified at each time point. For structural a

SUBMITTER: Georgevsky D 

PROVIDER: S-EPMC6774218 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature