A tissue-engineered scale model of the heart ventricle.

ABSTRACT: Laboratory studies of the heart use cell and tissue cultures to dissect heart function yet rely on animal models to measure pressure and volume dynamics. Here, we report tissue-engineered scale models of the human left ventricle, made of nanofibrous scaffolds that promote native-like anisotropic myocardial tissue genesis and chamber-level contractile function. Incorporating neonatal rat ventricular myocytes or cardiomyocytes derived from human induced pluripotent stem cells, the tissue-engineered ventricles have a diastolic chamber volume of ~500 µl (comparable to that of the native rat ventricle and approximately 1/250 the size of the human ventricle), and ejection fractions and contractile work 50-250 times smaller and 10⁴-10⁸ times smaller than the corresponding va

SUBMITTER: MacQueen LA 

PROVIDER: S-EPMC6774355 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature