Colorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy: a microsimulation modelling study.

ABSTRACT:

Objective

To estimate benefits and harms of different colorectal cancer screening strategies, stratified by (baseline) 15-year colorectal cancer risk.

Design

Microsimulation modelling study using MIcrosimulation SCreening ANalysis-Colon (MISCAN-Colon).

Setting

A parallel guideline committee (BMJ Rapid Recommendations) defined the time frame and screening interventions, including selection of outcome measures.

Population

Norwegian men and women aged 50-79 years with varying 15-year colorectal cancer risk (1-7%).

Comparisons

Four screening strategies were compared with no screening: biennial or annual faecal immunochemical test (FIT) or single sigmoidoscopy or colonoscopy at 100% adherence.

Main outcome measures

Colorectal cancer mortality an

SUBMITTER: Buskermolen M 

PROVIDER: S-EPMC6774435 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature