The Peak Index: Spirometry Metric for Airflow Obstruction Severity and Heterogeneity.

ABSTRACT: Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation. Spirometry loops are not smooth curves and have undulations and peaks that likely reflect heterogeneity of airflow.Objectives: To assess whether the Peak Index, the number of peaks adjusted for lung size, is associated with clinical outcomes.Methods: We analyzed spirometry data of 9,584 participants enrolled in the COPDGene study and counted the number of peaks in the descending part of the expiratory flow-volume curve from the peak expiratory flow to end-expiration. We adjusted the peaks count for the volume of the lungs from peak expiratory flow to end-expiration to derive the Peak Index. Multivariable regression analyses were performed to test associations between the Pea

SUBMITTER: Bhatt SP 

PROVIDER: S-EPMC6774744 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature