Emulating a Novel Clinical Trial Using Existing Observational Data. Predicting Results of the PreVent Study.

ABSTRACT: Rationale: "Target trial emulation" has been proposed as an observational method to answer comparative effectiveness questions, but it has rarely been attempted concurrently with a randomized clinical trial (RCT).Objectives: We tested the hypothesis that blinded analysts applying target trial emulation to existing observational data could predict the results of an RCT.Methods: PreVent (Preventing Hypoxemia with Manual Ventilation during Endotracheal Intubation) was a multicenter RCT examining the effects of positive-pressure ventilation during tracheal intubation on oxygen saturation and severe hypoxemia. Analysts unaware of PreVent's results used patient-level data from three previous trials evaluating airway management interventions to emulate PreVent's eligibility c

SUBMITTER: Admon AJ 

PROVIDER: S-EPMC6774748 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature