Hepatic PPARα is critical in the metabolic adaptation to sepsis.

ABSTRACT:

Background & aims

Although the role of inflammation to combat infection is known, the contribution of metabolic changes in response to sepsis is poorly understood. Sepsis induces the release of lipid mediators, many of which activate nuclear receptors such as the peroxisome proliferator-activated receptor (PPAR)α, which controls both lipid metabolism and inflammation. We aimed to elucidate the previously unknown role of hepatic PPARα in the response to sepsis.

Methods

Sepsis was induced by intraperitoneal injection of Escherichia coli in different models of cell-specific Ppara-deficiency and their controls. The systemic and hepatic metabolic response was analyzed using biochemical, transcriptomic and functional assays. PPARα expression was analyzed in livers from elective su

SUBMITTER: Paumelle R 

PROVIDER: S-EPMC6774768 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature