Ontology highlight
ABSTRACT:
SUBMITTER: Folgueira C
PROVIDER: S-EPMC6774781 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nature metabolism 20190819 8
Dopamine signaling is a crucial part of the brain reward system and can affect feeding behavior. Dopamine receptors are also expressed in the hypothalamus, which is known to control energy metabolism in peripheral tissues. Here we show that pharmacological or chemogenetic stimulation of dopamine receptor 2 (D2R) expressing cells in the lateral hypothalamic area (LHA) and the zona incerta (ZI) decreases body weight and stimulates brown fat activity in rodents in a feeding-independent manner. LHA/ ...[more]