Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism.

ABSTRACT: Both single and multicellular organisms depend on anti-stress mechanisms that enable them to deal with sudden changes in the environment, including exposure to heat and oxidants. Central to the stress response are dynamic changes in metabolism, such as the transition from the glycolysis to the pentose phosphate pathway-a conserved first-line response to oxidative insults^1,2. Here we report a second metabolic adaptation that protects microbial cells in stress situations. The role of the yeast polyamine transporter Tpo1p^3-5 in maintaining oxidant resistance is unknown⁶. However, a proteomic time-course experiment suggests a link to lysine metabolism. We reveal a connection between polyamine and lysine metabolism during stress situations, in the form of a prom

SUBMITTER: Olin-Sandoval V 

PROVIDER: S-EPMC6774798 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature