The extrinsic risk and its association with neural alterations in spasmodic dysphonia.

ABSTRACT:

Introduction

Spasmodic dysphonia (SD) is an isolated focal dystonia characterized by laryngeal spasms during voluntary voice production. Environmental factors have been assumed to play a role in SD pathophysiology; however, the exact extrinsic risk factors and their association with neural alterations remain unknown.

Methods

A total of 186 SD patients and 85 healthy controls completed a structured 177-question survey, consisting of questions on general biographical information, medical history, symptomatology of dystonia. Data were imputed in a stepwise regression model to identify extrinsic risk factors for SD. In addition, functional MRI data from a subset of this cohort were analyzed to determine brain activation abnormalities associated with the SD extrinsic risk.

Res

SUBMITTER: de Lima Xavier L 

PROVIDER: S-EPMC6774802 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature