Association of Epigenetic Clock with Consensus Molecular Subtypes and Overall Survival of Colorectal Cancer.

ABSTRACT:

Background

Epigenetic clock, or DNA methylation age, has been shown to highly correlate with chronologic age. Epigenetic age acceleration, the difference between DNA methylation age and individual's chronologic age, was observed in colorectal cancer. However, the association of epigenetic age acceleration with colorectal cancer tumor molecular characteristics, clinical characteristics, and patient outcomes has not been systematically investigated.

Methods

DNA methylation ages of 345 patients with colorectal cancer from The Cancer Genome Atlas (TCGA) were computed using the Horvath age prediction model. Multivariate linear regression was used to assess the association of epigenetic age acceleration with molecular and clinical features of colorectal cancer, including consensus

SUBMITTER: Zheng C 

PROVIDER: S-EPMC6774810 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature