The Immune Contexture Associates with the Genomic Landscape in Lung Adenomatous Premalignancy.

ABSTRACT: Epithelial cells in the field of lung injury can give rise to distinct premalignant lesions that may bear unique genetic aberrations. A subset of these lesions may escape immune surveillance and progress to invasive cancer; however, the mutational landscape that may predict progression has not been determined. Knowledge of premalignant lesion composition and the associated microenvironment is critical for understanding tumorigenesis and the development of effective preventive and interception strategies. To identify somatic mutations and the extent of immune cell infiltration in adenomatous premalignancy and associated lung adenocarcinomas, we sequenced exomes from 41 lung cancer resection specimens, including 89 premalignant atypical adenomatous hyperplasia lesions, 15 adenocarcinomas

SUBMITTER: Krysan K 

PROVIDER: S-EPMC6774823 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature