Human inborn errors of immunity to infection affecting cells other than leukocytes: from the immune system to the whole organism.

ABSTRACT: Studies of vertebrate immunity have traditionally focused on professional cells, including circulating and tissue-resident leukocytes. Evidence that non-professional cells are also intrinsically essential (i.e. not via their effect on leukocytes) for protective immunity in natural conditions of infection has emerged from three lines of research in human genetics. First, studies of Mendelian resistance to infection have revealed an essential role of DARC-expressing erythrocytes in protection against Plasmodium vivax infection, and an essential role of FUT2-expressing intestinal epithelial cells for protection against norovirus and rotavirus infections. Second, studies of inborn errors of non-hematopoietic cell-extrinsic immunity have shown that APOL1 and complement cascade components secret

SUBMITTER: Zhang SY 

PROVIDER: S-EPMC6774828 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature