Sex-specific roles of cellular inflammation and cardiometabolism in obesity-associated depressive symptomatology.

ABSTRACT:

Background

Obesity and depression are complex conditions with stronger comorbid relationships among women than men. Inflammation and cardiometabolic dysfunction are likely mechanistic candidates for increased depression risk, and their prevalence differs by sex. Whether these relationships extend to depressive symptoms is poorly understood. Therefore, we analyzed sex in associations between inflammation and metabolic syndrome (MetS) criteria on depressive symptomatology. Specifically, we examined whether sex positively moderates the relationship between depressive symptoms and inflammation among women, and whether MetS has parallel effects among men.

Methods

Depressive symptoms, MetS, and inflammation were assessed in 129 otherwise healthy adults. Depressive symptoms were as

SUBMITTER: Kohn JN 

PROVIDER: S-EPMC6774832 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature