Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation In Vivo.

ABSTRACT:

Purpose

The myeloproliferative neoplasms (MPN), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are characterized by the expansion of the erythroid, megakaryocytic, and granulocytic lineages. A common feature of these disorders is the presence of abnormal megakaryocytes, which have been implicated as causative agents in the development of bone marrow fibrosis. However, the specific contributions of megakaryocytes to MPN pathogenesis remain unclear.

Experimental design

We used Pf4-Cre transgenic mice to drive expression of JAK2^V617F in megakaryocyte lineage-committed hematopoietic cells. We also assessed the critical role of mutant megakaryocytes in MPN maintenance through cell ablation studies in JAK2^V617F</

SUBMITTER: Woods B 

PROVIDER: S-EPMC6774846 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature