Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma.

ABSTRACT:

Purpose

Naturally occurring primary canine lung cancers share clinicopathologic features with human lung cancers in never-smokers, but the genetic underpinnings of canine lung cancer are unknown. We have charted the genomic landscape of canine lung cancer and performed functional characterization of novel, recurrent HER2 (ERBB2) mutations occurring in canine pulmonary adenocarcinoma (cPAC).

Experimental design

We performed multiplatform genomic sequencing of 88 primary canine lung tumors or cell lines. Additionally, in cPAC cell lines, we performed functional characterization of HER2 signaling and evaluated mutation-dependent HER2 inhibitor drug dose-response.

Results

We discovered somatic, coding HER2 point mutations in 38% of cPACs (28/74), but none in

SUBMITTER: Lorch G 

PROVIDER: S-EPMC6774847 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature