Regional neuropathology distribution and verbal fluency impairments in Parkinson's disease.

ABSTRACT: BACKGROUND:Verbal fluency deficits are common in patients with Parkinson's disease. The association of these impairments with regional neuropathological changes is unexplored. OBJECTIVES:Determine if patients with verbal fluency impairments have greater neuropathological burden in frontal, temporal, and limbic regions and if Lewy bodies or neurofibrillary tangles were associated with verbal fluency impairments. METHODS:Data was derived from the Arizona Study of Aging and Neurodegenerative Disorders. 47 individuals who completed phonemic and semantic verbal fluency tasks and met clinicopathological criteria for Parkinson's disease (with and without comorbid Alzheimer's disease) were included. Impairment on fluency tasks was defined by normative data, and the density of neuropathology in tem

SUBMITTER: El-Nazer R 

PROVIDER: S-EPMC6774852 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature