Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer.

ABSTRACT: PURPOSE:The incidence rates of colorectal cancers are increasing in young adults. The objective of this study was to investigate genomic differences between tumor samples collected from younger and older patients with colorectal cancer. EXPERIMENTAL DESIGN:DNA was extracted from 18,218 clinical specimens, followed by hybridization capture of 3,769 exons from 403 cancer-related genes and 47 introns of 19 genes commonly rearranged in cancer. Genomic alterations (GA) were determined, and association with patient age and microsatellite stable/microsatellite instability high (MSS/MSI-H) status established. RESULTS:Overall genomic alteration rates in the younger (<40) and older (≥50) cohorts were similar in the majority of the genes analyzed. Gene alteration rates in the microsatellite stable (M

SUBMITTER: Lieu CH 

PROVIDER: S-EPMC6774873 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature