Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements.

ABSTRACT:

Background

Understanding the molecular mechanisms in perturbation of the metabolome following ischaemia and reperfusion is critical in developing novel therapeutic strategies to prevent the sequelae of post-injury shock. While the metabolic substrates fueling these alterations have been defined, the relative contribution of specific organs to the systemic metabolic reprogramming secondary to ischaemic or haemorrhagic hypoxia remains unclear.

Materials and methods

A porcine model of selected organ ischaemia was employed to investigate the relative contribution of liver, kidney, spleen and small bowel ischaemia/reperfusion to the plasma metabolic phenotype, as gleaned through ultra-high performance liquid chromatography-mass spectrometry-based metabolomics.

Results

Live

SUBMITTER: Clendenen N 

PROVIDER: S-EPMC6774928 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature