Within-host mathematical modelling of the incubation period of Salmonella Typhi.

ABSTRACT: Mechanistic mathematical models are often employed to understand the dynamics of infectious diseases within a population or within a host. They provide estimates that may not be otherwise available. We have developed a within-host mathematical model in order to understand how the pathophysiology of Salmonella Typhi contributes to its incubation period. The model describes the process of infection from ingestion to the onset of clinical illness using a set of ordinary differential equations. The model was parametrized using estimated values from human and mouse experimental studies and the incubation period was estimated as 9.6 days. A sensitivity analysis was also conducted to identify the parameters that most affect the derived incubation period. The migration of bacteria to the ca

SUBMITTER: Awofisayo-Okuyelu A 

PROVIDER: S-EPMC6774937 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature