Tuning of ion-release capability from bio-ceramic-polymer composites for enhancing cellular activity.

ABSTRACT: In our previous study, we investigated the synergetic effects of inorganic ions, such as silicate, Mg²⁺ and Ca²⁺ ions on the osteoblast-like cell behaviour. Mg²⁺ ions play an important role in cell adhesion. In the present study, we designed a new composite that releases a high concentration of Mg²⁺ ions during the early stage of the bone-forming process, and silicate and Ca²⁺ ions continuously throughout this process. Here, 40SiO₂-40MgO-20Na₂O glass (G) with high solubility and vaterite-based calcium carbonate (V) were selected as the source of silicate and Mg²⁺ and Ca²⁺ ions, respectively. These particles were mixed with poly(lactic-co-glycolic acid) (PLGA) using a kneading method at

SUBMITTER: Osada N 

PROVIDER: S-EPMC6774980 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature