Targeting CDC7 sensitizes resistance melanoma cells to BRAF^V600E-specific inhibitor by blocking the CDC7/MCM2-7 pathway.

ABSTRACT: Although the utilization of selective BRAF^V600E inhibitors is associated with improved overall survival in patients with metastatic melanoma, a growing challenge of drug resistance has  emerged. CDC7 has been shown to be overexpressed and associated with poor prognosis in various cancers including melanoma. Thus, we aimed to elucidate the biological role of CDC7 in promoting Vemurafenib resistance and the anticipated benefits of dual targeting of BRAF^V600E and CDC7 in melanoma cells. We performed exosomes-associated microRNA profiling and functional assays to determine the role of CDC7 in drug resistance using Vemurafenib-sensitive and resistant melanoma cells. Our results demonstrated that Vemurafenib-resistant cells exhibited a persistent expression of CDC7 in addit

SUBMITTER: Gad SA 

PROVIDER: S-EPMC6775054 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature