Comparative modulation of lncRNAs in wild-type and rag1-heterozygous mutant zebrafish exposed to immune challenge with spring viraemia of carp virus (SVCV).

ABSTRACT: Although the modulation of immune-related genes after viral infection has been widely described in vertebrates, the potential implications of non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), in immunity are still a nascent research field. The model species zebrafish could serve as a useful organism for studying the functionality of lncRNAs due to the numerous advantages of this teleost, including the existence of numerous mutant lines. In this work, we conducted a whole-transcriptome analysis of wild-type (WT) and heterozygous rag1 mutant (rag1^+/-) zebrafish after infection with the pathogen spring viraemia of carp virus (SVCV). WT and rag1^+/- zebrafish were infected with SVCV for 24 h. Kidney samples were sampled from infected and uninfected fish

SUBMITTER: Valenzuela-Munoz V 

PROVIDER: S-EPMC6775065 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature