New screening approach for Alzheimer's disease risk assessment from urine lipid peroxidation compounds.

ABSTRACT: Alzheimer Disease (AD) standard biological diagnosis is based on expensive or invasive procedures. Recent research has focused on some molecular mechanisms involved since early AD stages, such as lipid peroxidation. Therefore, a non-invasive screening approach based on new lipid peroxidation compounds determination would be very useful. Well-defined early AD patients and healthy participants were recruited. Lipid peroxidation compounds were determined in urine using a validated analytical method based on liquid chromatography coupled to tandem mass spectrometry. Statistical studies consisted of the evaluation of two different linear (Elastic Net) and non-linear (Random Forest) regression models to discriminate between groups of participants. The regression models fitted to the data from so

SUBMITTER: Pena-Bautista C 

PROVIDER: S-EPMC6775072 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature