Cellular reprogramming for successful CNS axon regeneration is driven by a temporally changing cast of transcription factors.

ABSTRACT: In contrast to mammals, adult fish display a remarkable ability to fully regenerate central nervous system (CNS) axons, enabling functional recovery from CNS injury. Both fish and mammals normally undergo a developmental downregulation of axon growth activity as neurons mature. Fish are able to undergo damage-induced "reprogramming" through re-expression of genes necessary for axon growth and guidance, however, the gene regulatory mechanisms remain unknown. Here we present the first comprehensive analysis of gene regulatory reprogramming in zebrafish retinal ganglion cells at specific time points along the axon regeneration continuum from early growth to target re-innervation. Our analyses reveal a regeneration program characterized by sequential activation of stage-specific pathways, regu

SUBMITTER: Dhara SP 

PROVIDER: S-EPMC6775158 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature