Trends in Alzheimer's Disease Research Based upon Machine Learning Analysis of PubMed Abstracts.

ABSTRACT: About 29.8 million people worldwide had been diagnosed with Alzheimer's disease (AD) in 2015, and the number is projected to triple by 2050. In 2018, AD was the fifth leading cause of death in Americans with 65 years of age or older, but the progress of AD drug research is very limited. It is helpful to identify the key factors and research trends of AD for guiding further more effective studies. We proposed a framework named as LDAP, which combined the latent Dirichlet allocation model and affinity propagation algorithm to extract research topics from 95,876 AD-related papers published from 2007 to 2016. Trends and hotspots analyses were performed on LDAP results. We found that the focus points of AD research for the past 10 years include 15 diseases, 15

SUBMITTER: Guan R 

PROVIDER: S-EPMC6775293 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature