Differential impact of classical and non-canonical NF-κB pathway-related gene expression on the survival of breast cancer patients.

ABSTRACT: Inflammation is a well-known driver of carcinogenesis and cancer progression, often attributed to the tumor microenvironment. However, tumor cells themselves are capable of secreting a variety of inflammatory molecules, leading to the activation of specific signaling pathways that promote tumor progression. The NF-κB signaling pathway is one of the most important connections between inflammation and tumorigenesis. NF-κB is a superfamily of transcription factors that plays an important role in several types of hematological and solid tumors, including breast cancer. However, the role of the NF-κB pathway in the survival of breast cancer patients is poorly studied. In this study, we analyzed and related the expression of both canonical and alternative NF-κB pathways and selected target genes

SUBMITTER: Espinoza-Sanchez NA 

PROVIDER: S-EPMC6775609 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature