Unknown

Dataset Information

0

The Kinome of Human Alveolar Type II and Basal Cells, and Its Reprogramming in Lung Cancer.

ABSTRACT: The discovery of mutant tyrosine kinases as oncogenic drivers of lung adenocarcinomas has changed the basic understanding of lung cancer development and therapy. Yet, expressed kinases (kinome) in lung cancer progenitor cells, as well as whether kinase expression and the overall kinome changes or is reprogrammed upon transformation, is incompletely understood. We hypothesized that the kinome differs between lung cancer progenitor cells, alveolar type II cells (ATII), and basal cells (BC) and that their respective kinomes undergo distinct lineage-specific reprogramming to adenocarcinomas and squamous cell carcinomas upon transformation. We performed RNA sequencing on freshly isolated human ATII, BC, and lung cancer cell lines to define the kinome in nontransformed cells and transformed cells. Our studies identified a unique kinome for ATII and BC and changes in their kinome upon transformation to their respective carcinomas.

SUBMITTER: Leach SM 

PROVIDER: S-EPMC6775950 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The Kinome of Human Alveolar Type II and Basal Cells, and Its Reprogramming in Lung Cancer.

Leach Sonia M SM   Finigan Jay J   Vasu Vihas T VT   Mishra Rangnath R   Ghosh Moumita M   Foster Daniel D   Mason Robert R   Kosmider Beata B   Farias Hesson Eveline E   Kern Jeffrey A JA  

American journal of respiratory cell and molecular biology 20191001 4

The discovery of mutant tyrosine kinases as oncogenic drivers of lung adenocarcinomas has changed the basic understanding of lung cancer development and therapy. Yet, expressed kinases (kinome) in lung cancer progenitor cells, as well as whether kinase expression and the overall kinome changes or is reprogrammed upon transformation, is incompletely understood. We hypothesized that the kinome differs between lung cancer progenitor cells, alveolar type II cells (ATII), and basal cells (BC) and tha  ...[more]