Early complement genes are associated with visual system degeneration in multiple sclerosis.

ABSTRACT: Multiple sclerosis is a heterogeneous disease with an unpredictable course and a wide range of severity; some individuals rapidly progress to a disabled state whereas others experience only mild symptoms. Though genetic studies have identified variants that are associated with an increased risk of developing multiple sclerosis, no variants have been consistently associated with multiple sclerosis severity. In part, the lack of findings is related to inherent limitations of clinical rating scales; these scales are insensitive to early degenerative changes that underlie disease progression. Optical coherence tomography imaging of the retina and low-contrast letter acuity correlate with and predict clinical and imaging-based outcomes in multiple sclerosis. Therefore, they may serve as sensiti

SUBMITTER: Fitzgerald KC 

PROVIDER: S-EPMC6776113 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature