Trajectory Analysis of Cognitive Outcomes in Children With Perinatal HIV.

ABSTRACT: BACKGROUND:Children with perinatal HIV (pHIV) may display distinct long-term cognitive phenotypes. We used group-based trajectory modeling to identify clusters of children with pHIV after similar developmental trajectories and predictors of belonging to select cognitive trajectory groups. METHODS:Participants included children, 4-17 years of age, with pHIV in Thailand and Cambodia. Cognitive measures included translated versions of Intelligence Quotient tests, Color Trails Tests and Beery-Buktenica Developmental Test of Visual-Motor Integration conducted semiannually over 3-6 years. The best fit of trajectory groups was determined using maximum likelihood estimation. Multivariate logistic regression identified baseline factors associated with belonging to the lowest scoring trajectory grou

SUBMITTER: Patel PB 

PROVIDER: S-EPMC6776249 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature