Prosthesis design of animal models of periprosthetic joint infection following total knee arthroplasty: A systematic review.

ABSTRACT: BACKGROUND:The number of periprosthetic joint infections (PJI) after total knee arthroplasty (TKA) is increasing annually. Animal models have been used to clarify their clinical characteristics and the infection mechanism of pathogenic bacteria, However, since the prosthesis design of animal models is not uniform, it is difficult to simulate the environment of clinical PJI. OBJECTIVES:To retrospect the progress on the prosthesis design of animal models of PJI after TKA and to summarize the criteria for evaluating a clinically representative model of PJI. METHODS:This systematic review was reported on the basis of Systematic Reviews and Meta-Analyzes (PRISMA). Pubmed, EMbase, Cochrane Library, Web of Science, Wanfang Data and China National Knowledge Infrastructure were researched for anima

SUBMITTER: Jie K 

PROVIDER: S-EPMC6776332 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature