Intermolecular interactions play a role in the distribution and transport of charged contrast agents in a cartilage model.

ABSTRACT: The transport and distribution of charged molecules in polyelectrolyte solutions are of both fundamental and practical importance. A practical example, which is the specific subject addressed in the present paper, is the transport and distribution of charged species into cartilage. The charged species could be a contrast agent or a drug molecule involved in diagnosis or treatment of the widespread degenerative disease osteoarthritis, which leads to degradation of articular cartilage. Associated scientific issues include the rate of transport and the equilibrium concentrations of the charged species in the cartilage and the synovial fluid. To address these questions, we present results from magnetic resonance micro-imaging experiments on a model system of articular cartilage. The experiment

SUBMITTER: Algotsson J 

PROVIDER: S-EPMC6776344 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature