Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: An interrupted time series analysis.

ABSTRACT: This study aimed to assess the impact of the Zika epidemic on the registration of birth defects in Brazil. We used an interrupted time series analysis design to identify changes in the trends in the registration of congenital anomalies. We obtained monthly data from Brazilian Live Birth Information System and used two outcome definitions: 1) rate of congenital malformation of the brain and eye (likely to be affected by Zika and its complications) 2) rate of congenital malformation not related to the brain or eye unlikely to be causally affected by Zika. The period between maternal infection with Zika and diagnosis of congenital abnormality attributable to the infection is around six months. We therefore used September 2015 as the interruption point in the time series, six months following

SUBMITTER: Paixao ES 

PROVIDER: S-EPMC6776346 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature