Chromosomal rearrangements as a source of new gene formation in Drosophila yakuba.

ABSTRACT: The origins of new genes are among the most fundamental questions in evolutionary biology. Our understanding of the ways that new genetic material appears and how that genetic material shapes population variation remains incomplete. De novo genes and duplicate genes are a key source of new genetic material on which selection acts. To better understand the origins of these new gene sequences, we explored the ways that structural variation might alter expression patterns and form novel transcripts. We provide evidence that chromosomal rearrangements are a source of novel genetic variation that facilitates the formation of de novo exons in Drosophila. We identify 51 cases of de novo exon formation created by chromosomal rearrangements in 14 strains of D. yakuba. These new genes inherit transc

SUBMITTER: Stewart NB 

PROVIDER: S-EPMC6776367 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature