Dimensions of control for subthreshold oscillations and spontaneous firing in dopamine neurons.

ABSTRACT: Dopaminergic neurons (DAs) of the rodent substantia nigra pars compacta (SNc) display varied electrophysiological properties in vitro. Despite this, projection patterns and functional inputs from DAs to other structures are conserved, so in vivo delivery of consistent, well-timed dopamine modulation to downstream circuits must be coordinated. Here we show robust coordination by linear parameter controllers, discovered through powerful mathematical analyses of data and models, and from which consistent control of DA subthreshold oscillations (STOs) and spontaneous firing emerges. These units of control represent coordinated intracellular variables, sufficient to regulate complex cellular properties with radical simplicity. Using an evolutionary algorithm and dimensionality reduction, we dis

SUBMITTER: Rumbell T 

PROVIDER: S-EPMC6776370 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature