Regulating the Basicity of Metal-Oxido Complexes with a Single Hydrogen Bond and Its Effect on C-H Bond Cleavage.

ABSTRACT: The functionalization of C-H bonds is an essential reaction in biology and chemistry. Metalloenzymes that often exhibit this type of reactivity contain metal-oxido intermediates that are directly involved in the initial cleavage of the C-H bonds. Regulation of the cleavage process is achieved, in part, by hydrogen bonds that are proximal to the metal-oxido units, yet our understanding of their exact role(s) is still emerging. To gain further information into the role of H-bonds on C-H bond activation, a hybrid set of urea-containing tripodal ligands has been developed in which a single H-bond can be adjusted through changes in the properties of one ureayl N-H bond. This modularity is achieved by appending a phenyl ring with different para-substituents from one ureayl NH group. The ligands

SUBMITTER: Barman SK 

PROVIDER: S-EPMC6776423 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature