A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.

ABSTRACT: Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA). SnoRNAs are altered in several cancers; however, their role in cell homeostasis as well as in cellular transformation remains poorly explored. Here, we show that specific subsets of snoRNAs are differentially regulated during the earliest cellular response to oncogenic RAS^G12V expression. We describe a novel function for one H/ACA snoRNA, SNORA24, which guides two pseudouridine modifications within the small ribosomal subunit, in RAS-induced senescence in vivo. We find that in mouse models, loss of Snora24 cooperates with RAS^G12V to promote the development of liver cancer

SUBMITTER: McMahon M 

PROVIDER: S-EPMC6776443 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature