Bradykinin-Mediated Angioedema: An Update of the Genetic Causes and the Impact of Genomics.

ABSTRACT: Recurrent episodes of bradykinin-mediated angioedema (Bk-AE) can associate with acquired or hereditary conditions, the former most commonly developing secondarily to a pharmacological treatment. Despite successful genomic advances that have led to the identification of a large number of disease genes irrespective of disease prevalence, their application to Bk-AE has barely occurred. As a consequence, the genetic causes of Bk-AE remain poorly understood, obstructing the identification of patient subtypes and the development of precision medicine strategies. This review provides an update of the genetic studies completed to date on the acquired forms, which have almost exclusively focused on Bk-AE secondarily to the angiotensin-converting enzyme inhibitor treatment, and the blooming subdivis

SUBMITTER: Marcelino-Rodriguez I 

PROVIDER: S-EPMC6776636 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature